Russian cancer vaccine developer announces tumor success
The first patient treated with Russia’s personalized cancer vaccine has recorded no new tumors over a four-month trial period, according to the developer of the revolutionary treatment.
Director of the Gamaleya Research Institute Alexander Gintsburg, who heads the trialing of Neooncovac, confirmed in an interview with Gazeta.ru on Wednesday that the patient’s metastases – cancer that had spread beyond the original tumor – have disappeared. Doctors continue to examine the patient monthly and plan to monitor his condition for another three years.
“Everything is fine with him. As of yesterday, no new growths had been detected,” Gintsburg said, adding that doctors use high-resolution CT scans to check for signs of cancer in the patient’s lymph nodes and throughout his body.
The patient, a 60-year-old man diagnosed with stage-three melanoma that had spread beyond the original tumor, began receiving Neooncovac in April at Moscow’s Herzen Oncology Research Institute. In July, Gintsburg reported that the patient was feeling well and had developed an immune response capable of fighting the cancer.
Neooncovac uses mRNA technology and is tailored to each patient. Researchers analyze genetic material from tumor and healthy tissue samples to develop a vaccine that trains the immune system to recognize and attack cancer cells.
Andrey Kaprin, head of the National Medical Research Center of Radiology, has described the technology as a fundamentally new approach to cancer treatment. Rather than directly targeting tumors, it aims to train the body’s immune system to identify and destroy malignant cells, he explained.
Gintsburg said the first patient occasionally developed a fever of 38-38.5C during treatment, which subsided within hours after taking standard fever-reducing medication. A second patient, now halfway through treatment, has experienced no fever, he added.
Six patients have received the vaccine so far, with 20 expected to undergo treatment at the Herzen institute by the end of the year. The program is also set to expand to other Russian regions.
The treatment is covered by Russia’s compulsory health insurance system, with the production of each personalized vaccine and the full course of therapy costing around 7 million rubles ($84,400) per patient, according to Gintsburg.
The Health Ministry has allocated funding to treat 120 patients this year and next, including follow-up monitoring. Researchers are also developing personalized vaccines against other forms of cancer, including pancreatic, kidney, bladder, colorectal, and non-small cell lung cancers, with regulatory approvals planned for 2027.
